ST segment elevation: the lost measure of early ischemic preconditioning in the landmark study of Murry et al. 1986.

Lean Ossabaw swine with the V199l AMPK mutation have impaired glucose tolerance and exacerbated K channel-mediated ST elevation during myocardial ischemia. Excess calorie diet induces MetS and abolishes cardioprotection in wild type AMPK swine. ST segment changes are an excellent measure of ischemic preconditioning in this model, thus showing the relevance of Murry's landmark discovery.