Stretch-induced Myocardial Injury and Inflammation After Transient Vasopressin-Mediated Left Ventricular Pressure Overload in Swine.

VP-TPO elicits myocardial injury, leukocyte mobilization, and an acute rise in circulating pro-inflammatory cytokines, thereby recapitulating several features of PE-TPO in the absence of direct α1-adrenergic stimulation. These findings suggest that stretch-induced myocardial injury provokes an inflammatory response that may play an important role in promoting the development of cardiac fibrosis and diastolic dysfunction after exposure to repetitive episodes of TPO.