Abdominal Aortic Aneurysm and Plasminogen Activator Inhibitor 1: Correlation in the Context of Type 2 Diabetes.

Our study demonstrated that PAI-1 is elevated in mice with STZ-induced diabetes. While hyperglycemic mice show significantly reduced AAA growth compared to normoglycemic AAA controls, no difference in aortic growth is observed between hyperglycemic and normoglycemic PAI-1 KO mice. Regardless of treatment status, PAI-1 deficient mice experience significantly reduced AAA growth compared to C57 control mice. We conclude that while the fibrinolytic pathway and PAI-1 are influential in AAA development, hyperglycemia-induced elevated PAI-1 expression does not play a crucial role in hyperglycemic inhibition of AAA growth. Conversely, PAI-1 deficiency appears to inhibit AAA growth regardless of glycemic status.