HIF1 alpha and NF kappa B Regulate Mineralocorticoid Receptor Gene Expression in Aging Human Vascular Smooth Muscle Cells
FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）
Abstract
The MR gene is regulated by the inflammatory transcription factor NFkB and by the hypoxia/oxidative stress-induced TF HIF1α, to increase MR expression in SMC of the aging human vasculature. This molecular insight may explain enhanced MR activity in cardiovascular aging and could potentially contribute to other cardiovascular conditions driven by oxidative stress and inflammation.
MoreTranslated text
Key words
vascular,aging
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined