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BRD4-MK2 SIGNALING: TARGET FOR CROHN'S DISEASE-ASSOCIATED FIBROSIS

Marina Chulkina,Steven McAninch,Yi Li,Walter Koltun,Gregory Yochum,Bing Tian,Jia Zhou,Ellen J Beswick,Allan R Brasier,Irina V Pinchuk

GASTROENTEROLOGY（2022）

Cited 0|Views14
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Abstract
Our data suggests that BRD4 positively regulates MK2 expression in CD. Further, BRD4-MK2 signaling is critical to profibrotic activation of mesenchymal cells in CD and is a potential therapeutic target to reverse CD-associated fibrosis.
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crohns,disease-associated
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