High fat diet disrupts diurnal interactions between small intestinal host innate immune factor REG3 gamma and gut microbiota resulting in metabolic dysfunction

Katya Frazier,Amal Kambal,Elizabeth A. Zale,Joseph F. Pierre,Nathaniel Hubert,Sawako Miyoshi,Jun Miyoshi,Daina Ringus,Dylan Harris,Karen Yang,Katherine Carroll,Jake Hermanson,John Chlystek,Katherine Overmyer,Candace Cham,Mark W. Musch,Joshua J. Coon,Eugene B. Chang,Vanessa Leone

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Together, these results demonstrate transkingdom co-evolved biological rhythms that are primarily influenced by diet, and reciprocal sensor-effector signals between host and microbial components. The diurnal dynamics of host innate immune factors and specific diet-induced ileal gut microbes are key for the maintenance of regional intestinal host-microbe interactions and metabolic homeostasis.

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