Agomelatine Ameliorates Obesity-Induced Kidney Injury through the Inhibition of Renal Fibrosis and Improvement of Impaired Autophagy.

Sasivimon Promsan,Nichakorn Phengpol,Prempree Sutthasupha,Anusorn Lungkaphin

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

These findings indicated that AGOM prevented kidney injury under obese condition via the inhibition of oxidative stress and fibrosis and improved impaired autophagy via regulating AMPK-mTOR-autophagy signaling pathways.

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关键词

impaired autophagy,renal fibrosis,obesity-induced

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