Exercise training improves cerebral endothelial function in juvenile and mature Ossabaw miniature-pigs.

Cameron J Morse,Zeyad El Karsh,Katie Y Turnbull, Nici N Scaefer,Yehia El Karsh,Rory A Marshall,Jude S Morton, Maria Jarque Trigo,T Dylan Olver

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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Abstract

These results show that despite being hyperglycemic, HIIT improved endothelial-dependent cerebral dilation in juvenile and mature pigs likely owing to enhanced NO bioavailability, secondary to decreased NOX and increased SOD signaling. Maturity was associated with lower levels of hyperglycemia and did not impair cerebral endothelial-dependent dilation.

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