Soluble Isoform of ST2 is a Cardiac Inducer of Collagen Deposition in an Ex Vivo Model of Obesity.

Massimilano M Corsi Romanelli, Chiara Copes,Elena Dozio,Clementina Sitzia, Emanuela Galliera,Elena Vianello

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Our results demonstrated in a co-culture system that obesity promotes sST2 increase in the heart and this promotes collagen releases by cardiac cells, suggesting sST2 role in activation of pro-fibrotic signaling and detrimental heart remodeling.

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