Yo-Yo Diet Has Adverse Effects on Cardiac Function and Insulin Sensitivity in Female Fischer Rats.

Despite normalization of BW, MAP and HR after 3 c-sFR periods, c-sFR rats had reduced heart and kidney function and higher insulin resistance when compared to CT rats. This study suggests individuals who engage in yo-yo dieting or have experienced BW cycling due to inadequate food intake from other causes (e.g., very low food security, war, natural disasters) are at increased risk for developing cardio-metabolic disease.