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The Influence of Activin on the Tumor Microenvironment in Colon Cancer Metastasis

Mark B. Wiley,Jessica Bauer,Kunaal Mehrotra,Jasmin Zessner-Spitzenberg,Lyonell Kone,Guilin Quiao,Karla Castellanos,David N. Church,Rachel S. Kerr,David J. Kerr,Paul Grippo,Ajay Maker,Barbara Jung

GASTROENTEROLOGY（2022）

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Abstract
Recent clinical trials explored the feasibility of activin A and TGFβ blockade in solid tumors. Data presented here supports complex and intertwined roles for activin and TGFβ signaling in colorectal cancer, both in immune activation as well as metastatic spread of advanced cancers.
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Key words
tumor microenvironment,activin,metastasis,cancer
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