Potential Mechanisms of NUR77-Mediated Signaling in the Aging Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）
Abstract
Our preliminary results indicate an age-dependent role of NUR77 in balancing a metabolic switch towards mitochondrial respiration in the RPE. Studies are ongoing to further dissect the NUR77-mediated signaling pathways in aging and ocular disease, and in determining if NUR77 overexpression may serve as potential therapy in diseases wherein RPE is compromised.
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Key words
aging retinal pigment epithelium,signaling
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