Fenofibrate induced-hepatomegaly and liver regeneration is PPAR alpha dependent and partially related to the activation of YAP pathway

Shicheng Fan,Yue Gao,Aijuan Qu,Yiming Jiang,Guomin Xie,Xinpeng Yao,Xiao Yang,Tomoki Yagai,Jianing Tian,Ruimin Wang,Frank J. Gonzalez,Min Huang,Huichang Bi

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

These studies revealed a novel role of fenofibrate in promoting liver enlargement and regeneration, which is PPARα dependent and partially related to the activation of YAP signaling pathway. These findings provide clinical relevance of fenofibrate as a potential medication for promoting liver regeneration.

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