IL-19 Regulates Atherosclerotic Plaque Progression via Lymphangiogenesis.

Amanda Peluzzo,Kyle Preston,Tani Leigh,Sheri Kelemen,Michael Autieri

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

These data suggest that IL-19 increases lymphatic vessel formation, potentially allowing RCT to take place to decrease plaque burden in atherosclerosis. Further studies will confirm IL-19's mechanistic pathway in LECs. We will also determine RCT and inflammatory cell trafficking by intravital microscopy. These results have the potential to shift our understanding toward a positive view of the association between the lymphatic system and atherosclerosis.

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