A protein mutated in Parkinson's disease prevents damage of metabolites and proteins caused by a glycolytic metabolite.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2022)
Abstract
The accumulation of cellular damage is suspected to contribute to aging and neurodegenerative diseases. Oxidative stress and environmental factors likely play a role, but other damaging agents likely remain to be discovered Here we report that an enzyme mutated in hereditary Parkinson's disease achieves the seemingly impossible task to prevent damage caused by a glycolytic metabolite without affecting the metabolite itself. Inactivation of this enzyme in model systems ranging from flies to human cells leads to the accumulation of a wide range of metabolites and proteins damaged by a newly discovered covalent modification. Thus, this enzyme represents a highly conserved strategy to prevent damage in cells that perform glycolysis. Thereby, it interrupts a fundamental link between carbohydrate metabolism and a type of cellular damage that might contribute to the development of Parkinson's disease.
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Key words
parkinson,proteins,metabolites,disease
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