The role of master regulators such as HMGA1, SOX9, FOXA1 in the development of triple-negative breast cancer.

These results illustrate sharp transcriptomic and proteomic differences between TNBC and TPBC. HMGA1 has been identified to be overexpressed in various cancers and it regulates the expression of various other genes. It works with various molecular partners that essentially play a role in the development of breast cancer. FOXA1 another master regulator which we found is a tumor suppressor and is downregulated in the TNBC group compared to the TPBC group. The absence of ER, PR, and HER2 expression in TNBC shapes gene and protein expression and activities in consequential ways underscored by these pathways, interactions, and master regulators.