Loss of Myosin Vb leads to dysregulation of colonic goblet cell structure and function
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2022)
摘要
Our data shows that loss of functional Myo5b in the colonic epithelium results in decreased goblet cell numbers and alterations in mucin composition. These data suggest that Myo5b may play an important role in goblet cell mucus production and that mutations affecting Myo5b function may contribute to IBD.
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关键词
colonic goblet cell structure,myosin vb
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