Autophagic State Confers Facultative Stem Cell Capacity in The Intestinal Epithelium.

Louis R Parham, Nicolette Johnson,Jeeyoon Na,Alena Klochkova,Patrick Williams,Ning Li,Kelly A Whelan,Christopher J Lengner,Kathryn E Hamilton

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Our new data support the notion that epithelial cells in a high autophagic state are biased to secretory lineages and that autophagy status functions as a lineage agnostic marker of f-ISCs. Furthermore, our data suggests that autophagy is required for organoid formation in these lineages.

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