Aging Female Offspring Exposed to Maternal Hyperandrogenemia have Increased Renal Mitochondrial Content and Decreased Mitochondrial Reactive Oxygen Species.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）
Abstract
Aging female HAF offspring have increased renal mitochondrial LCFA and MCFA oxidation that is due to increased mitochondrial content. They also have decreased mtROS production indicating a protection against renal mitochondria-mediated oxidative stress compared to controls. Further studies are needed to determine if these differences have a mechanistic link to the protection against Ang II HT and whether there are changes in renal mitochondrial function following Ang II infusion in female HAF offspring.
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Key words
maternal hyperandrogenemia,renal mitochondrial content,female offspring
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