The Role of FXR1 and Senescence in Vascular Biology and Intimal Hyperplasia.

Cali Corbett,Amanda St Paul,Tani Leigh,Rachael Okune,Kyle Preston,Sheri Kelemen,Michael Autieri

FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）

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摘要

Our results are the first to suggest that in addition to destabilization of inflammatory transcripts, FXR1 may stabilize cell cycle related genes in VSMC, and absence of FXR1 leads to induction of a senescent phenotype, an increase in SASP gene expression, and reduction of intimal hyperplasia.

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