Mother with Obesity Induced by High-Fat Diet Impaired Autophagic Process and Induced Renal Lipid Accumulation in the Offspring.

Maternal obesity affected to program offspring obese-insulin resistance and increased the risk of kidney injury. The stimulation of renal lipogenesis and the suppression of renal lipolysis led to increased renal lipid accumulation. Moreover, maternal obesity induced impaired autophagic process by decreasing autophagosome formation and impaired lysosome formation. These alterations reduced the hydrolyzation of lipid droplet in the offspring's kidney leading to more severity of renal lipid accumulation and resulting in offspring's kidney injury.