Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae

B Haridevamuthu,Tamilvelan Manjunathan,Ajay Guru,Carlton Ranjith Wilson Alphonse,Seenivasan Boopathi,Raghul Murugan,Mansour K Gatasheh,Ashraf Atef Hatamleh,Annie Juliet,Pushparathinam Gopinath,Jesu Arockiaraj

Brain Research（2022）

引用 29|浏览4

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摘要

•Hydroxyl-containing benzo[b]thiophene analogs display neuroprotective function.•The analogs (BP and EP) enhance the glutathione redox dynamics.•Analogs BP and EP reduce oxidative stress and neuro inflammation.•The analogs BP and EP improve locomotory behavior.•BP and EP could be potential leads for the neurological disorder.

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关键词

Acrylamide,Glutathione,Neurological disorder,Oxidative stress,Animal behavior

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