Regioselective Access to 2-Iminoimidazolidines via AgF-Mediated Cascade Reactions

A convergent access to substituted 2-iminoimida-zolidines from aromatic amines andN-propargylS-methylthioureais developed via Ag(I)-mediated cascade guanylation-cyclizationreactions. This method features high regioselectivity, excellentefficiency, and mild reaction conditions. Subsequent deprotectionof the Boc (tert-butyloxycarbonyl) group under acidic conditionsprovides expedient access to aryl 2-aminoimidazole derivatives in aconvenient manner.