Novel Rgd-Containing Peptides Exhibited Improved Abilities to Integrin Receptor Binding and Cultures of Human Induced Pluripotent Stem Cells

•Design novel peptides from the nearing aspartic acid sequence of two reported Arg-Gly-Asp (RGD)-containing peptides.•Improve the ability of peptides in the culture of human induced pluripotent stem cells.•The mechanism underlies peptide sequence-induced cell culture ability is revealed in detail.•The high affinity between peptides and corresponding integrin receptors positively correlates to its ability in cell culture.