An immune complex binding model predicts effector cell response across diverse disease models

1. An immune complex binding model predicts effector cell response across diverse disease models Z. Cyrillus Tan, Anja Lux, Markus Biburger, Stephen Lees, Falk Nimmerjahn, Aaron S. Meyer University of California Los Angeles Friedrich-Alexander-University of Erlangen-Nürnberg Antibodies are crucial and central regulators of the immune response. Those of the IgG isotype interact with Fc gamma receptors on effector cells. The effector response of IgGs encompasses multiple cell types (e.g., macrophages, monocytes, etc.) and multiple processes (e.g., antigen presentation, cytokine response, phagocytosis, etc.). An individual IgG can be either proor anti-inflammatory depending upon its Fc domain composition and the context. IgGs are particularly versatile agents for therapeutic treatment due to their immunotherapeutic effects as well as those of direct antigen binding and opsonization. Indeed, IgG molecules comprise a broad range of approved therapies, many of which are known to rely in part on effector cell response. At the same time, the multiplicity throughout—of constant region composition, Fc gamma receptors, cell populations, and antigen binding in combination—makes precisely understanding, measuring, and manipulating effector function a yet-elusive goal.