The Relationship Between Thyroid Diseases and Irisin Hormone

Introduction: The aim of this study is to investigate the relationship between irisin, a new test with similar effects on energy metabolism and thermogenesis, and thyroid hormones. Material and Methods: 86 subjects included in the study. The subjects were divided into three groups as euthyroid, hypothyroid and hyperthyroid group by evaluating their TSH and fT4 levels. For all subjects, gender, age, medical history and blood test results were examined. Irisin levels of all groups were measured. Statistical analysis was performed with the obtained data. Results: A total of 86 people; 30 patients with newly diagnosed hypothyroidism, 28 patients with newly diagnosed hyperthyroidism and 28 euthyroid individuals as the control group were included in the study.The mean irisin level was highest in the hyperthyroid group and lowest in the hypothyroid group. The mean irisin level was found to be significantly higher in the hyperthyroid group than in the hypothyroid and control group (p˂0.01).The irisin level was found to be significantly higher in the control group than in the hypothyroid group (p˂0.01). A statistically significant negative correlation was found between the irisin levels and TSH levels (p˂0.01). A statistically significant positive correlation was found between the irisin levels and fT4,fT3 levels (p˂0.01). Conclusion: A significant correlation has been found between the TSH,fT3,fT4 and irisin.It was found that as TSH levels increase, irisin levels decreased and that as fT3, fT4 levels increase, irisin levels increased.We believe that irisin can be used as a new test in the follow-up and diagnosis of thyroid diseases, with studies with larger sample size and long-term follow-up in future.