A Physiological Mathematical Model of Heart Rate Response to Fluid Perturbation Presenting

Assessment of PCLC medical devices through comprehensive clinical trials is often costly. In conjunction with smaller clinical trials, mathematical models can be leveraged to evaluate a device's performance under different physiological conditions [1]. These models give control over different parameters and enable the simulation of a virtual cohort of patients under a wide range of physiological states for testing medical devices [2], [3].