Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Hilary A. Robbins,Karine Alcala,Elham Khodayari Moez,Florence Guida,Sera Thomas, Hana Zahed,Matthew T. Warkentin,Karl Smith-Byrne,Yonathan Brhane,David Muller,Xiaoshuang Feng,Demetrius Albanes,Melinda C. Aldrich,Alan A. Arslan,Julie Bassett,Christine D. Berg,Qiuyin Cai,Chu Chen,Michael P.A. Davies,Brenda Diergaarde

Annals of Epidemiology（2022）

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摘要

The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL.

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关键词

Lung cancer screening,early detection,biomarkers,risk prediction,nodule malignancy,biomarker discovery and validation,study design

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