Influence of FLG loss-of-function mutations in host–microbe interactions during atopic skin inflammation

•Eczema patients carrying filaggrin mutations present equal or moderately higher severity than matched wild-type patients.•More extensive dysregulation of gene expression is present in filaggrinWt lesions than in filaggrinMut•A lower threshold of onset in filaggrinMut and a „longer route” required for the same manifestation in filaggrinWt.