VAC_20-Virucidal activity evaluation of hydrogen peroxide wipes against the AZD1222-chimpanzee adenovirus in active pharmaceutical ingredient and the recombinant COVID-19 vaccine

semanticscholar(2022)

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Abstract
Introduction: Viral contaminations in cell culture-based biotech manufacturing can result in substantial plant downtimes, financial losses, and in delay in delivery of life-saving products. For an effective risk mitigation strategy preventive measures, including disinfection of surfaces, should be validated. Disinfectants with based on hydrogen peroxide have been used due to their practicality and non-residue generation. However, the effectiveness of these products on surfaces must be previously evaluated in different surfaces, including the presence of the matrix.
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