A Review of Necrotising Fasciitis and Treatment Strategies

Necrotizing fasciitis can be defined as infections of any of the layers within the soft tissue compartment that are associated with necrotizing changes. Bacterial growth within the superficial fascia releases a mixture of enzymes, endotoxins and exotoxins causing the spread of infection through this fascia. This process results in poor microcirculation, ischemia in affected tissues, and ultimately, cell death and necrosis. Diagnosis of NF is essentially clinical. The gold standard is surgical exploration and tissue biopsy. The treatment for NF is a combination of surgical debridement as well as appropriate antibiotics and optimal oxygenation of the infected tissues. S M Sandhya, Aranya K Sreekumar, Jibin John, Kavya Shyam, Reshma S Reghu, Prasobh G R, Swathy S ** Vice Principal, Head Of Department of Pharmaceutical Chemistry, Sree Krishna College of Pharmacy and Research Centre ,Thiruvananthapuram , Kerala , India 1.Fifth year Pharm D, Sree Krishna College of Pharmacy and Research Centre, Thiruvananthapuram , Kerala , India. 2 Principal, Head Of Department of Pharmacy Practice, Sree Krishna College of Pharmacy and Research Centre, Thiruvananthapuram , Kerala , India . 3. Assistant Professor, Sree Krishna College of Pharmacy and Research Centre, Thiruvananthapuram,