Human neural networks with sparse TDP-43 pathology reveal NPTX 2 misregulation in 1 ALS / FTLD 2 3

1 ALS/FTLD 2 3 Marian Hruska-Plochan1, Katharina M. Betz1,2,3*, Silvia Ronchi4*, Vera I. Wiersma1, Zuzanna Maniecka1, 4 Eva-Maria Hock1, Florent Laferriere1, Sonu Sahadevan1, Vanessa Hoop2, Igor Delvendahl2, Martina 5 Panatta1, Alexander van der Bourg5, Dasa Bohaciakova7, Karl Frontzek6, Adriano Aguzzi6, Tammaryn 6 Lashley8,9, Mark D. Robinson2,3, Theofanis Karayannis5, Martin Mueller2, Andreas Hierlemann4, 7 Magdalini Polymenidou1# 8 1Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, 9 Switzerland 10 2Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, 11 Switzerland 12 3SIB Swiss Institute of Bioinformatics, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, 13 Switzerland 14 4Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, 4058 Basel, 15 Switzerland 16 5Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland 17 6Institute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland 18 7Department of Histology and Embryology, Faculty of Medicine, Masaryk University Brno, Kamenice 3, 19 62500, Brno, Czech Republic 20