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Prevalence of Rate of Deleterious Copy Number Variants Similar in Early Onset Psychosis and Autism Spectrum Disorders: Implications for Clinical Practice

Catherine A. Brownstein,Elise Douard,Josephine Mollon,Richard Smith,Margaret Hojlo,Emily Garvey, Joshua Bowen, Abhijit Mondal,Casie Genetti,Devon Carroll,Emma Deaso,Emma Knowles,Pankaj Agrawal,Alan Beggs,Eugene D'Angelo,Laura Almasy,Clara Moreau,Zohra Saci,Guillaume Huguet,Sebastien Jacquemont,David Glahn,Joseph Gonzalez-Heydrich

Biological Psychiatry（2021）

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Abstract
Copy number variants (CNVs) are strongly associated with neurodevelopmental and psychotic disorders. Early onset psychosis (EOP), where symptoms appear before 18 years of age, are thought to be more strongly influenced by genetic factors than adult-onset psychotic disorders. However, the prevalence and pathogenicity of CNVs in EOP is unclear.
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Key words
Copy Number Variants, Early Onset Psychosis, Schizophrenia (SCZ), Autism Spectrum Disorder and Related Syndromes
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