Association Between Coronary Artery Disease And Clinical Outcome In Cancer Patients: A Propensity Score Matching Analysis
Research Square (Research Square)(2022)
Abstract
Abstract The aim of this study was to evaluate the prognostic value of coronary computed tomography angiography (CTA) to predict the risk of all-cause mortality in cancer patients in a propensity score matching (PSM) analysis. A total of 331 patients who previously had cancer and underwent coronary CTA from January 2015 to December 2019 were included. Multivariate Cox proportional hazards regression analysis and propensity-score matching analysis were performed. The primary endpoint was all-cause of mortality. In total, 125 with obstructive coronary artery disease (CAD) and 206 with non-obstructive CAD during a median follow-up of 3.3 years were included in this study. After PSM, age (HR, 1.040; 95%CI, 1.001-1.081; p =0.046), smoking history (HR, 2.344; 95%CI, 1.211-4.536; p =0.011), diabetes mellitus (HR, 1.862; 95%CI, 1.053-3.292; p =0.033) and obstructive CAD (HR, 1.845; 95%CI, 1.008-3.377; p =0.047) remained significant factors for all-cause mortality. Obstructive CAD evaluated by coronary CTA was found to be at higher risk for developing all-cause mortality in cancer patients.
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Key words
propensity score,coronary artery disease,clinical outcome,cancer patients
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