Genetic overlap between major depression , bipolar disorder and Alzheimer ' s 1 Disease 2 3

Genetic overlap between major depression, bipolar disorder and Alzheimer's 1 Disease 2 3 Fernanda C. Dos Santos, PhD; Ana Paula Mendes-Silva, PhD; Yuliya S. Nikolova, 4 PhD; Etienne L. Sibille, PhD; Breno Satler Diniz, MD, PhD 5 6 Institutional affiliations 7 1. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental 8 Health (CAMH), Toronto, ON M5T 1R8, Canada 9 2. Department of Psychiatry, Faculty of Medicine, University of Toronto, ON M5S 1A8, 10 Canada 11 3. Department of Pharmacology and Toxicology, University of Toronto, ON M5S 1A8, 12 Canada 13 4. Center on Aging, University of Connecticut Health Center, Farmington, CT 06030, 14 USA 15 16 * Corresponding authors: 17 Fernanda C. Dos Santos 18 250 College Street 19 Toronto, ON, Canada 20 M5T 1R8 21 Email: fernanda.santos@camh.ca 22 Breno S. Diniz 23 250 College Street 24 Toronto, ON, Canada 25 All rights reserved. No reuse allowed without permission. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted May 4, 2021. ; https://doi.org/10.1101/2021.05.01.21256220 doi: medRxiv preprint