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244 words Introduction: 501 words Discussion: 1492 words Abbreviations: CYP, cytochrome P450; ABC transporter, ATP-binding cassette transporter; NR, nuclear receptor; TF, transcriptional factor; AhR, aryl hydrocarbon receptor; LXR, liver X receptor; PPAR, peroxisome proliferator-activated receptor; RXR, retinoid X receptor; PXR, pregnane X receptor; CAR, constitutive androstane receptor, ER, estrogen receptor; FXR, farnesoid X receptor; CPR, cytochrome P450 reductase; FDXR, ferredoxin reductase; MnSOD, manganese superoxide dismutase; IRE1alpha: microsomal inositol-requiring enzyme 1 alpha; PCA, principal component analysis; BBB, blood-brain barrier; qRT-PCR, quantitative reverse transcriptase polymerase chain reaction. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on April 9, 2009 as DOI: 10.1124/dmd.109.027011 at A PE T Jornals on M arch 9, 2022 dm d.aspurnals.org D ow nladed from