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Data-Derived Subtypes of Treatment-Resistant Depression and Their Biomarker Correlates - A Pilot Study

Xiaowei Chen,Heidi De Smedt,Wayne Drevets,Guang Chen

Biological Psychiatry（2022）

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Abstract
Approximately 20-30% of individuals with major depressive disorder ultimately develop treatment-resistant depression (TRD). Detecting TRD subtypes and revealing their underlying biology are essential for developing novel treatments, biomarkers, and clinical trial patient stratification approaches.
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Key words
Treatment-Resistant Depression, Treatment-Resistant Depression Subtypes, Biomarkers, Data-Derived, Pilot Study
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