Polygonum persicaria L. alleviated oxidative damage and hepatotoxicity induced by carbon tetrachloride in Wistar rats

BACKGROUND AND OBJECTIVE: Liver illnesses can be metabolic, poison-induced, or infectious and are the fifth greatest cause of death worldwide. Several traditional medicinal plants have been utilized to treat liver diseases in the past. The goal of this study is to see how effective an aqueous extract of Polygonum persicaria L. roots is in protecting the liver from CCl4 toxicity in adult Wistar rats. MATERIALS AND METHODS: Aqueous extract of P. persicaria L. root sections was tested in CCl4-injured Wistar rats in vitro and in vivo. Animals were randomly assigned to normal control, toxic control, standard control (silymarin 100 mg/kg) groups and P. persicaria L. (200 and 400 mg/kg) treatment groups. Histopathology and serum biochemical markers of liver damage were investigated. The extract was examined for phytochemicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) in vitro. RESULTS: Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin levels in CCl4-damaged rats were all balanced after oral administration of the aqueous extract at 200 and 400 mg/kg/BW/day. In addition, when compared with silymarin therapy, histology of the liver revealed that P. persicaria L. restored tissue injury. Alkaloids, flavonoids, tannins, sterols, and saponins were found to be present in P. persicaria L. The actions of antioxidants are shown in the DPPH method. CONCLUSION: According to the results of this study, P. persicaria L. can reduce hepatotoxicity and oxidative pressure in vitro and in vivo. The ability of the extract to prevent lipid peroxidation and boost antioxidant enzymatic activity could account for this effect.