LGG subtypes based on the activity changes of immunologic and hallmark gene sets in cancer

Abstract Purpose: When glioma is in WHO grade II-III, glioma is of low grade. Gliomas in this period have the opportunity for surgical treatment and can be treated with a range of targeted therapies to enhance patient survival. Methods: In this study, we downloaded low-grade glioma data from TCGA database and GSEA database. Cancer subtypes were classified by GSVA enrichment method.Results: By GSVA enrichment analysis, we obtain three low-grade gliomas (LGG) cancer subtypes. After further survival prognosis analysis and biological function analysis, we obtained 21 tumor microenvironment gene sets and 17 core genes that affect patients' survival prognosis, and these genes have the potential to become targets for targeted therapies and disease detection.Conclusion: We screened a total of 21 gene sets through a series of enrichment analyses, statistical and prognostic analyses, etc. Among them, 17 core genes were identified, namely: TOP2A, KIF20A, CCNB2, AURKA, KIF11, CDK1, BUB1B, CCNA2, BUB1, CDC20, CDCA8, TPX2, KIF2C, POLA2, POLE2, POLA1 and POLE. TOP2A.