Generated randomly and selected functionally ? The nature of 1 enterovirus recombination 2 3

1 enterovirus recombination 2 3 Fadi G. Alnaji*, Kirsten Bentley*, Ashley Pearson, Andrew Woodman, Jonathan Moore, Helen Fox, 4 Andrew MacAdam and David J. Evans 5 6 1 Department of Microbiology, University of Illinois Champaign-Urbana, Champaign-Urbana, 601 E. John 7 St, Illinois, 61801, USA. 8 2 Biomedical Sciences Research Complex and School of Biology, University of St Andrew, St. Andrews 9 KY16 9ST 10 3 Department of Biochemistry & Molecular Biology, 201 Althouse Lab, University Park, PA 16802, USA. 11 4 John Innes Centre, Cell and Developmental Biology, Norwich, NR4 7UH, UK. 12 5 Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, 13 EN6 3QG, UK. 14 15 # Current address: Infection & Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 16 4XN, UK 17 * To whom correspondence should be addressed. Email: falnaji@illinois.edu and bentleyk@cardiff.ac.uk 18 19