Effect of a Low Dose Aripiprazole in Elderly Depressive Patient Who Presented with Hyperprolactinemia Associated with Administration of Sulpiride

Objective: We report one elderly depressive patient who presented with hyperprolactinemia associated with administration of sulpiride. Methods: The dose of low dose aripiprazole was administered without reducing the dose of sulpiride. Results: After 7 weeks of aripiprazole therapy, the blood prolactine level dropped from 159 to 33 (ng/ml), and was almost normalized. Furthermore, during the course of treatment, the present case did not show a worsening in psychiatric symptoms or aripiprazole-related side effects. Conclusion: Our results suggest that administration of low dose aripiprazole may be effective when elderly patient presents with hyperprolactinemia associated with sulpiride administration.