Mitochondrial bioenergetics and cardiolipin remodeling deregulation in mitochondrial trifunctional protein (TFP) deficiency
Genetics in Medicine(2022)
Abstract
Fatty acid oxidation (FAO) disorders show a wide variety of clinical phenotypes, degrees of severity, age of onset, organ involvement, and long-term survival, which may range from severe, fatal neonatal to adolescent/adult onset with recurrent rhabdomyolysis. The phenotype in defects of long-chain FAOs includes fasting and stress induced hypoketotic hypoglycemia, cardiomyopathy and arrhythmias, skeletal myopathy and recurrent rhabdomyolysis, progressive axonal peripheral neuropathy, and degenerative retinopathy.
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Key words
cardiolipin remodeling deregulation,mitochondrial bioenergetics alterations,trifunctional protein,deficiency
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