Stereoselective total synthesis of (-)-curvularin

Muniganti Radha Krishna,Gattu Sridhar,Tasqeeruddin Syed,H. V. Jayaprakash

Synthetic Communications（2022）

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摘要

A concise total synthesis of (-)-Curvularin have been synthesized from commercially available (S)-(−)-propylene epoxide and (3,5-Dimethoxyphenyl)acetic acid. The key steps involved in the synthesis are Vilsmeier-Haack formylation, Grignard reaction, alkylation of 1,3-dithiane and Yamaguchi macrolactonization.

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关键词

(-)-Curvularin,grignard reaction,1,3-dithiane,vilsmeier-haack formylation,yamaguchi macrolactonization

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