Genomic evidence supports a clonal diaspora model for metastases of esophageal 1 adenocarcinoma 2 3

MRC Cancer Unit, University of Cambridge, Biomedical Campus, Cambridge, CB2 OXZ, UK 10 Department of Histopathology, Papworth Hospital NHS Trust, Cambridge, CB23 3RE, UK 11 Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, New Mexico, 87545, USA 12 Cancer Research UK Cambridge Research Institute, Cambridge, CB2 0RE, UK 13 Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, UK 14 Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, 15