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Malonic Acid-Type Fullerene Derivatives Strongly Inhibit The SARS-Cov-2 Main Protease

Daiki Katagishi,Daisuke Yasuda,Kyoko Takahashi,Shigeo Nakamura,Tadahiko Mashino,Tomoyuki Ohe

Research Square (Research Square)（2022）

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Abstract
Abstract COVID-19 is a disease that is causing a global pandemic. There is an urgent need to develop new drugs to treat it. In this study, we evaluated the inhibitory activities of a series of fullerene derivatives against the main protease of SARS-CoV-2, the virus that causes COVID-19. As a result, it was found that the malonic acid-type fullerene derivatives showed strong inhibitory activities.
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Key words
fullerene derivatives,main protease,acid-type,sars-cov
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