Plasma P‐tau181 and NfL are central nodes in a network of diagnostic, biomarker, and demographic data

In Alzheimer’s disease (AD), plasma biomarkers of neurodegeneration and phosphorylated tau have initial support for their relationship to clinical diagnosis and cognitive outcomes over time (total tau [t‐tau], neurofilament light [NfL], and p‐tau). To date, only one study has assessed a network model with these data. Here, we assessed the network relations (i.e., conditional dependencies) between diagnostic variables, plasma biomarkers, neuropsychological test performance, and demographic variables using a Gaussian graphical model (GGM) with participants from the Boston University (BU) Alzheimer’s Disease Research Center (ADRC) Longitudinal Clinical Core Registry.