Pubertal Evolutionary Profile of Children Monitored for Fetal Ovarian Cyst (FOC Study)

Objective: To evaluate the outcomes of puberty in girls followed for Fetal Ovarian Cysts (FOC). Design: We included 83 girls of eight and more, followed at Toulouse Hospital for FOC. Historical data were collected through computerized medical record. Recent clinical, US and hormonal data were collected through a questionnaire filled up by the patients and their parents. Results: Of 83 eligible patients, 51 agreed to participate. Their median age was 11.6 years [8.6-17.6], 37 patients (72.5%) had pubertal signs, 18 patients had menarche (36%). The median age of puberty onset was 11 years 95% CI (10.5-11.5) and that of first menstruation was 13 years 95% CI (12.213.6). Fifty-two patients (96%) had no recurrence of ovarian cysts. No significant difference in the age of menarche, AMH levels, ovarian volume was noted. Regarding the 54 FOC including 3 bilateral cysts, 32 were simple (59.3%) and 22 (41%) were complex. The rate of cyst regression is 90% of cases in 2.1 months [0-8.9] for simple cysts and 54% of cases in 3.7 months [1.1-10.2] of complex cysts (rate p<0.0001 and time p=0.06). 23 small Cysts (diameter <40 mm) regressed in 90% of cases against 56% for the largest cysts (n=31) (p=0.01). The duration of regression of small cysts was 1.9 months, significantly less than that of largest cysts (median 3.4 months) punctured or not (p=0.05). Conclusion: The occurrence of FOC, whether liquid or complex, does not modify the pubertal profile, and no recurrence was observed.