Prognostic Factors for Cancer Therapeutics-Related Cardiac Dysfunction in Breast Cancer Patients Treated with Current Anthracycline Regimens
semanticscholar(2021)
摘要
Background
Anthracycline therapies cause myocardial damage and the onset of heart failure, depending on their doses. We investigated prognostic factors for cancer therapeutics-related cardiac dysfunction (CTRCD) in patients receiving modern anthracycline therapies.
Methods
Of 472 breast cancer patients with complete data treated with anthracycline, 8 were diagnosed with CTRCD.
Results
Multivariate regression analyses revealed that the anthracycline cumulative dose, concomitant use of molecular targeted drugs and a prechemotherapy left ventricular ejection fraction < 50% were independent and significant predictors of the onset of CTRCD.
Conclusions
Even in the modern era, the anthracycline cumulative dose is an independent risk factor for the onset of CTRCD.
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