Manifestations of sars-cov-2-induced covid-19 on the skin and oral mucosa

Over the past centuries, it is difficult to find diseases similar in resonance to the coronа-virus infection COVID-19 caused by SARS-CoV-2. From the day of manifestation of the infection, it has become the dominant nosology, and its etiological agent has dramatically changed, in its favor, the species spectrum of anthropogenic pathological microorganisms. The review is devoted to the skin manifestations of new coronovirus infection (SARS-CoV-2), information about which is constantly updated. However, this information has not been systematized yet. The purpose of this review is to analyze the dermatological manifestations of a new coronavirus infection. On average, 12.5—20.4% of patients with confirmed COVID-19 have developed skin manifestations. The question of whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself remains open at the moment. The possible mechanisms of development of skin lesions and the role of diseases of complement system and blood hypercoagulation in the pathogenesis of the disease are discussed in the article. The review also provides descriptive and clinical examples of skin manifestations in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days, skin manifestations can be an indicator of infection, which leads to the timely diagnosis. In addition, doctors' awareness about skin symptoms associated with COVID-19 infection plays a big role in preventing misdiagnosis of the disease. Keywords: COVID-19, SARS-CoV-2, Skin, Oral Mucosa.