Reinforcing the function of bone graft via the Ca-P ceramics dynamic behavior-enhanced osteogenic microenvironment for optimal bone regeneration and reconstruction

Jinjie Wu,Rongfeng Zhang,Yang Li,Xiupeng Zhu,Xuening Chen,Jie Weng,Wei Zhi,Jianxin Wang,Zhao Xie,Xingdong Zhang

Applied Materials Today（2022）

Cited 2|Views12

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Abstract

•Constructing a favorable osteogenic microenvironment for MSCs through the coupling of MVS and BCP ceramics.•MVS coupled with BCP ceramics endow DFBGs with functional activity via activating Piezo1-ERK1/2 and FAK-ERK1/2 signaling axis.•DFBGs exhibit better cell viability and osteogenic differentiation in vitro.•DFBGs promote new bone formation in situ compared with BGs in rat femur bone defect model.

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Key words

Ceramic,Micro-vibration,Bone tissue engineering,Mechanical adaptability,Osteogenesis

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